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Wei and colleagues (Wei et al., 2022) recently discovered that GLP-1 receptor activation inhibits this signaling pathway by modulating ROCK activity, leading to a reduction in the phosphorylation of MLC, which stabilizes the endothelial cell cytoskeleton and tight junctions by upregulating the expression of tight junction proteins such as Occludin and ZO-1

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During the Wegovy and Ozempic drug shortages of 20232024, the FDA temporarily allowed 503A and 503B compounding pharmacies to legally produce compounded versions of semaglutide